Human chorionic gonadotropin and alpha-fetoprotein in testicular germ cell tumors. An immunohistochemical study in comparison with tissue concentrations

Cancer ◽  
1983 ◽  
Vol 52 (7) ◽  
pp. 1281-1289 ◽  
Author(s):  
Shojiroh Morinaga ◽  
Motoko Ojima ◽  
Nobuaki Sasano
Keyword(s):  
Germ Cell ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Immunohistochemical Study ◽  
Germ Cell Tumors ◽  
Alpha Fetoprotein ◽  
Testicular Germ Cell Tumors ◽  
Tissue Concentrations ◽  
Testicular Germ Cell

Expression of human chorionic gonadotropin in testicular germ cell tumors

2014 ◽  
Vol 32 (5) ◽  
pp. 727-734 ◽  
Author(s):  
Anna Lempiäinen ◽  
Anna Sankila ◽  
Kristina Hotakainen ◽  
Caj Haglund ◽  
Carl Blomqvist ◽  
...  
Keyword(s):  
Germ Cell ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell

Serum and Cerebrospinal Fluid Human Chorionic Gonadotropin (hCG) and alpha-fetoprotein (AFP) in Intracranial Germ Cell Tumors

2002 ◽  
Vol 17 (2) ◽  
pp. 112-118 ◽  
Author(s):  
E. Seregni ◽  
M. Massimino ◽  
S. Nerini Molteni ◽  
F. Pallotti ◽  
B. van der Hiel ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Germ Cell ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Germ Cell Tumors ◽  
High Serum ◽  
Response To Therapy ◽  
Alpha Fetoprotein ◽  
Intracranial Germ Cell Tumors

We report a retrospective study on serum and cerebrospinal fluid (CSF) alpha-fetoprotein (AFP) and β-human chorionic gonadotropin (βhCG) determination in a series of 30 patients bearing intracranial germ cell tumors. At diagnosis five patients had high serum and CSF AFP levels. No patient had positive serum AFP and negative CSF AFP or vice versa. Twelve of 30 patients had serum βhCG levels above 5 mIU/mL, eight had high βhCG only in CSF, and ten were completely negative. During treatment and follow-up both markers were accurate indicators of the response to therapy, decreasing rapidly and often becoming normal already after the first phase of treatment. We conclude that these two markers, and mostly βhCG, may be useful in the diagnosis and monitoring of the response to therapy of patients with intracranial germ cell tumors.

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